7-cyano-7-deazaguanine synthase explained

7-Cyano-7-deazaguanine synthase
Ec Number:	6.3.4.20

7-cyano-7-deazaguanine synthase (preQ0 synthase, 7-cyano-7-carbaguanine synthase, queC (gene)) is an enzyme with systematic name 7-carboxy-7-carbaguanine:ammonia ligase (ADP-forming).^{[1] [2]} This enzyme catalyses the following chemical reaction

7-carboxy-7-carbaguanine + NH₃ + ATP

\rightleftharpoons 7-cyano-7-carbaguanine + ADP + phosphate + H₂O

This enzyme binds Zn²⁺.

Notes and References

1. McCarty RM, Somogyi A, Lin G, Jacobsen NE, Bandarian V . The deazapurine biosynthetic pathway revealed: in vitro enzymatic synthesis of PreQ(0) from guanosine 5'-triphosphate in four steps . Biochemistry . 48 . 18 . 3847–52 . May 2009 . 19354300 . 2693876 . 10.1021/bi900400e .
2. Cicmil N, Huang RH . Crystal structure of QueC from Bacillus subtilis: an enzyme involved in preQ1 biosynthesis . Proteins . 72 . 3 . 1084–8 . August 2008 . 18491386 . 10.1002/prot.22098 .