7-Chloro-L-tryptophan oxidase explained

7-chloro-L-tryptophan oxidase
Ec Number:1.4.3.23

7-Chloro-L-tryptophan oxidase (RebO) is an enzyme with systematic name 7-chloro-L-tryptophan:oxygen oxidoreductase.[1] [2] This enzyme catalyses the following chemical reaction

7-chloro-L-tryptophan + O2

\rightleftharpoons

2-imino-3-(7-chloroindol-3-yl)propanoate + H2O2

This enzyme contains a noncovalently bound FAD.

Notes and References

  1. Nishizawa T, Aldrich CC, Sherman DH . Molecular analysis of the rebeccamycin L-amino acid oxidase from Lechevalieria aerocolonigenes ATCC 39243 . Journal of Bacteriology . 187 . 6 . 2084–92 . March 2005 . 15743957 . 1064027 . 10.1128/JB.187.6.2084-2092.2005 .
  2. Howard-Jones AR, Walsh CT . Enzymatic genеration of the chromopyrrolic acid scaffold of rebeccamycin by the tandem action of RebO and RebD . Biochemistry . 44 . 48 . 15652–63 . December 2005 . 16313168 . 10.1021/bi051706e . 10.1.1.537.5773 .

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