7-carboxy-7-deazaguanine synthase explained

7-carboxy-7-deazaguanine synthase
Ec Number:	4.3.99.3

7-Carboxy-7-deazaguanine synthase (EC 4.3.99.3, 7-carboxy-7-carbaguanine synthase, queE (gene)) is an enzyme with systematic name 6-carboxy-5,6,7,8-tetrahydropterin ammonia-lyase.^[1] This enzyme catalyses the following chemical reaction

6-carboxy-5,6,7,8-tetrahydropterin

\rightleftharpoons

7-carboxy-7-carbaguanine + NH₃

The enzyme is a member of the superfamily of S-adenosyl-L-methionine-dependent radical enzymes.

Notes and References

McCarty RM, Somogyi A, Lin G, Jacobsen NE, Bandarian V . The deazapurine biosynthetic pathway revealed: in vitro enzymatic synthesis of PreQ₀ from guanosine 5′-triphosphate in four steps . Biochemistry . 48 . 18 . 3847–52 . May 2009 . 19354300 . 2693876 . 10.1021/bi900400e .