7-Methyl-α-ethyltryptamine explained

7-Methyl-α-ethyltryptamine (7-Me-αET) is a tryptamine derivative related to α-ethyltryptamine (αET). It was discovered by a team at Upjohn in the early 1960s. It has similar pharmacological effects to αET, but is both 3-4 times more potent as a serotonin releasing agent, and 10 times more potent as a monoamine oxidase inhibitor,^{[1] [2]} making it potentially hazardous as this pharmacological profile is shared with drugs such as PMA and 4-MTA, which are known to be dangerous in humans when used at high doses.

See also

• 4-Methyl-αET
• 5-Fluoro-αMT
• 5-Fluoro-αET
• 7-Methyl-DMT
• 7-Chloro-AMT

Notes and References

1. Hester JB, Greig ME, Anthony WC, Heinzelman RV, Szmuszkovicz J . Enzyme Inhibitory Activity of 3-(2-Aminobutyl)indole Derivatives . Journal of Medicinal Chemistry . 7 . 3 . 274–9 . May 1964 . 14204959 . 10.1021/jm00333a006 .
2. Burningham RA, Arimura GK, Yunis AA . Effect of Monase and related compounds on uptake of 5-hydroxytryptamine by platelets . Proceedings of the Society for Experimental Biology and Medicine . 122 . 3 . 711–4 . July 1966 . 5918937 . 10.3181/00379727-122-31233 . 24949288 .