7β-Hydroxy-DHEA explained

7β-Hydroxydehydroepiandrosterone (7β-hydroxy-DHEA; 7β-OH-DHEA), also known as 3β,7β-dihydroxyandrost-5-ene-17-one, is an endogenous, naturally occurring steroid and a metabolite of dehydroepiandrosterone (DHEA). The major metabolic pathway of DHEA outside the liver is via 7-hydroxylation into 7α-OH-DHEA and 7β-OH-DHEA.^[1] 7β-OH-DHEA has weak antiestrogenic activity, selectively antagonizing the estrogen receptor ERβ.^[2]

7β-OH-DHEA is on the World Anti-Doping Agency list of prohibited substances in sporting.^[3]

See also

• 7-Keto-DHEA
• 7α-Hydroxyepiandrosterone
• 7β-Hydroxyepiandrosterone

Notes and References

1. Li H, Liu HM, Ge W, Huang L, Shan L . Synthesis of 7alpha-hydroxy-dehydroepiandrosterone and 7beta-hydroxy-dehydroepiandrosterone . Steroids . 70 . 14 . 970–3 . 2005 . 16143359 . 10.1016/j.steroids.2005.07.006 . 53294855 . he major metabolic pathway for DHEA in extra-hepatic tissues is via 7-hydroxylation [18], [19] and [20]..
2. Miller KK, Al-Rayyan N, Ivanova MM, Mattingly KA, Ripp SL, Klinge CM, Prough RA . DHEA metabolites activate estrogen receptors alpha and beta . Steroids . 78 . 1 . 15–25 . 2013 . 23123738 . 3529809 . 10.1016/j.steroids.2012.10.002 .
3. Web site: What is Prohibited. 2020-01-09. 2020-11-12. https://web.archive.org/web/20201112011132/https://www.wada-ama.org/en/content/what-is-prohibited/prohibited-at-all-times/anabolic-agents. dead.