7,8,3'-Trihydroxyflavone Explained
7,8,3′-Trihydroxyflavone (7,8,3'-THF) is a flavone and small-molecule agonist of TrkB, the main receptor of brain-derived neurotrophic factor (BDNF), that was derived from tropoflavin (7,8-DHF).[1] [2] Relative to tropoflavin, 7,8,3'-THF is 2–3-fold more potent in vitro as a TrkB agonist. 7,3’-Dihydroxyflavone (7,3'-DHF) is also more potent than tropoflavin in vitro, indicating that a 3'-hydroxy group on the B-ring enhances TrkB agonistic activity. 7,8,3'-THF has been tested in vivo and was found to produce TrkB-dependent neuroprotective effects in mice similarly to tropoflavin.[3]
See also
- Tropomyosin receptor kinase B § Agonists
Notes and References
- Liu X, Chan CB, Jang SW, Pradoldej S, Huang J, He K, Phun LH, France S, Xiao G, Jia Y, Luo HR, Ye K . 6 . A synthetic 7,8-dihydroxyflavone derivative promotes neurogenesis and exhibits potent antidepressant effect . Journal of Medicinal Chemistry . 53 . 23 . 8274–86 . December 2010 . 21073191 . 3150605 . 10.1021/jm101206p .
- Yu Q, Chang Q, Liu X, Gong S, Ye K, Lin X . 7,8,3'-Trihydroxyflavone, a potent small molecule TrkB receptor agonist, protects spiral ganglion neurons from degeneration both in vitro and in vivo . Biochemical and Biophysical Research Communications . 422 . 3 . 387–92 . June 2012 . 22575512 . 3388121 . 10.1016/j.bbrc.2012.04.154 .
- Yu Q, Chang Q, Liu X, Wang Y, Li H, Gong S, Ye K, Lin X . 6 . Protection of spiral ganglion neurons from degeneration using small-molecule TrkB receptor agonists . The Journal of Neuroscience . 33 . 32 . 13042–52 . August 2013 . 23926258 . 3735884 . 10.1523/JNEUROSCI.0854-13.2013 .
