60S ribosomal protein L39 explained

60S ribosomal protein L39 is a protein that in humans is encoded by the RPL39 gene.^{[1] [2]}

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the S39E family of ribosomal proteins. It is located in the cytoplasm. In rat, the protein is the smallest, and one of the most basic, proteins of the ribosome. This gene is co-transcribed with the U69 small nucleolar RNA gene, which is located in its second intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.

Further reading

• Wool IG, Chan YL, Glück A . Structure and evolution of mammalian ribosomal proteins . Biochem. Cell Biol. . 73 . 11–12 . 933–47 . 1996 . 8722009 . 10.1139/o95-101 .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Yoshihama M . The Human Ribosomal Protein Genes: Sequencing and Comparative Analysis of 73 Genes . Genome Res. . 12 . 3 . 379–90 . 2002 . 11875025 . 10.1101/gr.214202 . 155282 . vanc. Uechi T . Asakawa S . 3 . Kawasaki . K . Kato . S . Higa . S . Maeda . N . Minoshima . S . Tanaka . T .
• Uechi T, Tanaka T, Kenmochi N . A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders . Genomics . 72 . 3 . 223–30 . 2001 . 11401437 . 10.1006/geno.2000.6470 .
• Tsui SK . Primary structures and sequence analysis of human ribosomal proteins L39 and S27 . Biochem. Mol. Biol. Int. . 40 . 3 . 611–6 . 1997 . 8908372 . 10.1080/15216549600201203. vanc. Lee SM . Fung KP . 3 . Waye . MM . Lee . CY . 7909023 . free.
• Kato S . Construction of a human full-length cDNA bank . Gene . 150 . 2 . 243–50 . 1995 . 7821789 . 10.1016/0378-1119(94)90433-2 . vanc. Sekine S . Oh SW . 3 . Namsoon . K . Yuri . U . Naoto . A . Midori . Y . Takashi . A .

Notes and References

1. Otsuka S, Tanaka M, Saito S, Yoshimoto K, Itakura M . Molecular cloning of a cDNA encoding human ribosomal protein L39 . Biochim Biophys Acta . 1308 . 2 . 119–21 . Sep 1996 . 8764829 . 10.1016/0167-4781(96)00106-6.
2. Web site: Entrez Gene: RPL39 ribosomal protein L39.