60S ribosomal protein L37 explained

60S ribosomal protein L37 is a protein that in humans is encoded by the RPL37 gene.^{[1] [2] [3]}

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L37E family of ribosomal proteins. It is located in the cytoplasm. The protein contains a C2C2-type zinc finger-like motif. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[3]

Further reading

• Wool IG, Chan YL, Glück A . Structure and evolution of mammalian ribosomal proteins. . Biochem. Cell Biol. . 73 . 11–12 . 933–47 . 1996 . 8722009 . 10.1139/o95-101 .
• Su S, Bird RC . Cell cycle, differentiation and tissue-independent expression of ribosomal protein L37 . Eur. J. Biochem. . 232 . 3 . 789–97 . 1995 . 7588717 . 10.1111/j.1432-1033.1995.tb20874.x .
• Uechi T, Tanaka T, Kenmochi N . A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders . Genomics . 72 . 3 . 223–30 . 2001 . 11401437 . 10.1006/geno.2000.6470 .
• Yoshihama M, Uechi T, Asakawa S, etal . The Human Ribosomal Protein Genes: Sequencing and Comparative Analysis of 73 Genes . Genome Res. . 12 . 3 . 379–90 . 2002 . 11875025 . 10.1101/gr.214202 . 155282 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Schwartz EI, Intine RV, Maraia RJ . CK2 Is Responsible for Phosphorylation of Human La Protein Serine-366 and Can Modulate rpL37 5′-Terminal Oligopyrimidine mRNA Metabolism . Mol. Cell. Biol. . 24 . 21 . 9580–91 . 2004 . 15485924 . 10.1128/MCB.24.21.9580-9591.2004 . 522270 .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Ewing RM, Chu P, Elisma F, etal . Large-scale mapping of human protein–protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 .

Notes and References

1. Barnard GF, Staniunas RJ, Puder M, ((Steele GD Jr)), Chen LB . Human ribosomal protein L37 has motifs predicting serine/threonine phosphorylation and a zinc-finger domain . Biochim Biophys Acta . 1218 . 3 . 425–8 . Sep 1994 . 7545944 . 10.1016/0167-4781(94)90197-x.
2. Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC . A map of 75 human ribosomal protein genes . Genome Res . 8 . 5 . 509–23 . Aug 1998 . 9582194 . 10.1101/gr.8.5.509. free .
3. Web site: Entrez Gene: RPL37 ribosomal protein L37.