60S ribosomal protein L35 explained

60S ribosomal protein L35 is a protein that in humans is encoded by the RPL35 gene.^{[1] [2]}

Function

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L29P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.

Further reading

• Wool IG, Chan YL, Glück A . Structure and evolution of mammalian ribosomal proteins. . Biochem. Cell Biol. . 73 . 11–12 . 933–47 . 1996 . 8722009 . 10.1139/o95-101 .
• Ou JH, Yen TS, Wang YF . Cloning and characterization of a human ribosomal protein gene with enhanced expression in fetal and neoplastic cells. . Nucleic Acids Res. . 15 . 21 . 8919–34 . 1988 . 2891103 . 10.1093/nar/15.21.8919 . 306413 . etal.
• Kato S, Sekine S, Oh SW . Construction of a human full-length cDNA bank. . Gene . 150 . 2 . 243–50 . 1995 . 7821789 . 10.1016/0378-1119(94)90433-2 . etal.
• Matoba R, Okubo K, Hori N . The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression. . Gene . 146 . 2 . 199–207 . 1994 . 8076819 . 10.1016/0378-1119(94)90293-3 . etal.
• Mammalian Gene Collection Program Team . 4 . Strausberg . R. L. . Feingold . E. A. . Grouse . L. H. . Derge . J. G. . Klausner . R. D. . Collins . F. S. . Wagner . L. . Shenmen . C. M. . Schuler . G. D. . 10.1073/pnas.242603899 . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . . 99 . 26 . 16899–16903 . 139241 . 2002 . 12477932. 2002PNAS...9916899M . free .
• Odintsova TI, Müller EC, Ivanov AV . Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. . J. Protein Chem. . 22 . 3 . 249–58 . 2004 . 12962325 . 10.1023/A:1025068419698 . 10710245 . etal.
• Bouwmeester T, Bauch A, Ruffner H . A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. . Nat. Cell Biol. . 6 . 2 . 97–105 . 2004 . 14743216 . 10.1038/ncb1086 . 11683986 . etal.
• Humphray SJ, Oliver K, Hunt AR . DNA sequence and analysis of human chromosome 9. . Nature . 429 . 6990 . 369–74 . 2004 . 15164053 . 10.1038/nature02465 . 2734081 . 2004Natur.429..369H . etal.
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Andersen JS, Lam YW, Leung AK . Nucleolar proteome dynamics. . Nature . 433 . 7021 . 77–83 . 2005 . 15635413 . 10.1038/nature03207 . 2005Natur.433...77A . 4344740 . etal.
• Oh JH, Yang JO, Hahn Y . Transcriptome analysis of human gastric cancer. . Mamm. Genome . 16 . 12 . 942–54 . 2006 . 16341674 . 10.1007/s00335-005-0075-2 . 69278 . etal.
• Ewing RM, Chu P, Elisma F . Large-scale mapping of human protein-protein interactions by mass spectrometry. . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 . etal.

Notes and References

1. Uechi T, Tanaka T, Kenmochi N . A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders . Genomics . 72 . 3 . 223–30 . Jun 2001 . 11401437 . 10.1006/geno.2000.6470 .
2. Web site: Entrez Gene: RPL35 ribosomal protein L35.