60S ribosomal protein L26 explained

60S ribosomal protein L26 is a protein that in humans is encoded by the RPL26 gene.^{[1] [2]}

Function

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L24P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome and the human paralog RPL26L1.^[2]

Interactions

RPL26 has been shown to interact with Mdm2.^[3]

See also

• Eukaryotic translation
• 60S ribosomal subunit

Further reading

• Wool IG, Chan YL, Glück A . Structure and evolution of mammalian ribosomal proteins . Biochem. Cell Biol. . 73 . 11–12 . 933–47 . 1996 . 8722009 . 10.1139/o95-101 .
• Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC . A map of 75 human ribosomal protein genes . Genome Res. . 8 . 5 . 509–23 . 1998 . 9582194 . 10.1101/gr.8.5.509 . free .
• Uechi T, Tanaka T, Kenmochi N . A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders . Genomics . 72 . 3 . 223–30 . 2001 . 11401437 . 10.1006/geno.2000.6470 .
• Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI . Directed proteomic analysis of the human nucleolus . Curr. Biol. . 12 . 1 . 1–11 . 2002 . 11790298 . 10.1016/S0960-9822(01)00650-9 . 14132033 . free . 2002CBio...12....1A .
• Yoshihama M, Uechi T, Asakawa S, Kawasaki K, Kato S, Higa S, Maeda N, Minoshima S, Tanaka T, Shimizu N, Kenmochi N . The Human Ribosomal Protein Genes: Sequencing and Comparative Analysis of 73 Genes . Genome Res. . 12 . 3 . 379–90 . 2002 . 11875025 . 155282 . 10.1101/gr.214202 .
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . Large-scale mapping of human protein–protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human 60S ribosomal protein L26

Notes and References

1. Zaman GJ . Sequence of a cDNA encoding human ribosomal protein L26 and of a cDNA probably encoding human ribosomal protein L6 . Nucleic Acids Res . 21 . 7 . 1673 . May 1993 . 8479925 . 309386 . 10.1093/nar/21.7.1673 .
2. Web site: Entrez Gene: RPL26 ribosomal protein L26.
3. Ofir-Rosenfeld Y, Boggs K, Michael D, Kastan MB, Oren M . Mdm2 regulates p53 mRNA translation through inhibitory interactions with ribosomal protein L26 . Mol. Cell . 32 . 2 . 180–9 . Oct 2008 . 18951086 . 2587494 . 10.1016/j.molcel.2008.08.031 .