6-phospho-3-hexuloisomerase explained
| 6-phospho-3-hexuloisomerase |
| Ec Number: | 5.3.1.27 |
6-phospho-3-hexuloisomerase (3-hexulose-6-phosphate isomerase, phospho-3-hexuloisomerase, PHI, 6-phospho-3-hexulose isomerase, YckF) is an enzyme with systematic name D-arabino-hex-3-ulose-6-phosphate isomerase.[1] [2] [3] [4] [5] [6] This enzyme catalyses the following chemical reaction
D-arabino-hex-3-ulose 6-phosphate
D-fructose 6-phosphate
This enzyme plays a key role in the ribulose-monophosphate cycle of formaldehyde fixation.
Notes and References
- Ferenci T, Strom T, Quayle JR . Purification and properties of 3-hexulose phosphate synthase and phospho-3-hexuloisomerase from Methylococcus capsulatus . The Biochemical Journal . 144 . 3 . 477–86 . December 1974 . 4219834 . 1168525 . 10.1042/bj1440477 .
- Yurimoto H, Kato N, Sakai Y . Assimilation, dissimilation, and detoxification of formaldehyde, a central metabolic intermediate of methylotrophic metabolism . Chemical Record . 5 . 6 . 367–75 . 2005 . 16278835 . 10.1002/tcr.20056 .
- Kato N, Yurimoto H, Thauer RK . The physiological role of the ribulose monophosphate pathway in bacteria and archaea . Bioscience, Biotechnology, and Biochemistry . 70 . 1 . 10–21 . January 2006 . 16428816 . 10.1271/bbb.70.10 .
- Orita I, Yurimoto H, Hirai R, Kawarabayasi Y, Sakai Y, Kato N . The archaeon Pyrococcus horikoshii possesses a bifunctional enzyme for formaldehyde fixation via the ribulose monophosphate pathway . Journal of Bacteriology . 187 . 11 . 3636–42 . June 2005 . 15901685 . 1112069 . 10.1128/jb.187.11.3636-3642.2005 .
- Martinez-Cruz LA, Dreyer MK, Boisvert DC, Yokota H, Martinez-Chantar ML, Kim R, Kim SH . Crystal structure of MJ1247 protein from M. jannaschii at 2.0 A resolution infers a molecular function of 3-hexulose-6-phosphate isomerase . Structure . 10 . 2 . 195–204 . February 2002 . 11839305 . 10.1016/s0969-2126(02)00701-3 . free .
- Taylor EJ, Charnock SJ, Colby J, Davies GJ, Black GW . Cloning, purification and characterization of the 6-phospho-3-hexulose isomerase YckF from Bacillus subtilis . Acta Crystallographica Section D . 57 . Pt 8 . 1138–40 . August 2001 . 11468398 . 10.1107/s090744490100748x .
