6-Hydroxypseudooxynicotine dehydrogenase explained

6-hydroxypseudooxynicotine dehydrogenase
Ec Number:1.5.99.14

6-hydroxypseudooxynicotine dehydrogenase is an enzyme with systematic name 1-(6-hydroxypyridin-3-yl)-4-(methylamino)butan-1-one:acceptor 6-oxidoreductase (hydroxylating).[1] [2] [3] This enzyme catalyses the following chemical reaction:

1-(6-hydroxypyridin-3-yl)-4-(methylamino)butan-1-one + acceptor + H2O

\rightleftharpoons

1-(2,6-dihydroxypyridin-3-yl)-4-(methylamino)butan-1-one + reduced acceptor

This enzyme contains a cytidylyl molybdenum cofactor.

Notes and References

  1. Nicotine dehydrogenase from Arthrobacter oxidans: A molybdenum-containing hydroxylase . Freudenberg W, Konig K, Andreesen JR . FEMS Microbiology Letters . 1988 . 52 . 13–18 . 10.1111/j.1574-6968.1988.tb02564.x. free .
  2. Grether-Beck S, Igloi GL, Pust S, Schilz E, Decker K, Brandsch R . Structural analysis and molybdenum-dependent expression of the pAO1-encoded nicotine dehydrogenase genes of Arthrobacter nicotinovorans . Molecular Microbiology . 13 . 5 . 929–36 . September 1994 . 7815950 . 10.1111/j.1365-2958.1994.tb00484.x .
  3. Sachelaru P, Schiltz E, Brandsch R . A functional mobA gene for molybdopterin cytosine dinucleotide cofactor biosynthesis is required for activity and holoenzyme assembly of the heterotrimeric nicotine dehydrogenases of Arthrobacter nicotinovorans . Applied and Environmental Microbiology . 72 . 7 . 5126–31 . July 2006 . 16820521 . 1489357 . 10.1128/AEM.00437-06 .

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