6-Hydroxynicotinate 3-monooxygenase explained

6-Hydroxynicotinate 3-monooxygenase
Ec Number:1.14.13.114

6-Hydroxynicotinate 3-monooxygenase (NicC, 6HNA monooxygenase, HNA-3-monooxygenase) is an enzyme with systematic name 6-hydroxynicotinate,NADH:oxygen oxidoreductase (3-hydroxylating, decarboxylating).[1] [2] This enzyme catalyses the following chemical reaction

6-hydroxynicotinate + NADH + H+ + O2

\rightleftharpoons

2,5-dihydroxypyridine + NAD+ + H2O + CO2

6-Hydroxynicotinate 3-monooxygenase a flavoprotein (FAD).

Notes and References

  1. Nakano H, Wieser M, Hurh B, Kawai T, Yoshida T, Yamane T, Nagasawa T . Purification, characterization and gene cloning of 6-hydroxynicotinate 3-monooxygenase from Pseudomonas fluorescens TN5 . European Journal of Biochemistry . 260 . 1 . 120–6 . February 1999 . 10091591 . 10.1046/j.1432-1327.1999.00124.x . free .
  2. Jiménez JI, Canales A, Jiménez-Barbero J, Ginalski K, Rychlewski L, García JL, Díaz E . Deciphering the genetic determinants for aerobic nicotinic acid degradation: the nic cluster from Pseudomonas putida KT2440 . Proceedings of the National Academy of Sciences of the United States of America . 105 . 32 . 11329–34 . August 2008 . 18678916 . 2516282 . 10.1073/pnas.0802273105 . 2008PNAS..10511329J . free .

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