6-Hydroxymellein Explained

6-Hydroxymellein is a dihydroisocoumarin, a phenolic compound found in carrots.^[1] It has also been isolated in Aspergillus terreus and shows an inhibition of pollen development in Arabidopsis thaliana.^[2]

Biosynthesis

6-Methoxymellein is formed from S-adenosyl methionine and 6-hydroxymellein by the enzyme 6-hydroxymellein O-methyltransferase with secondary production of S-adenosylhomocysteine.^[3]

Notes and References

1. Kurosaki . F. . Nishi . A. . 10.1016/0014-5793(88)80894-9 . A methyltransferase for synthesis of the phytoalexin 6-methoxymellein in carrot cells . FEBS Letters . 227 . 2 . 183 . 1988 . 86402868 . free .
2. Shimada . A. . Kusano . M. . Takeuchi . S. . Fujioka . S. . Inokuchi . T. . Kimura . Y. . Aspterric acid and 6-hydroxymellein, inhibitors of pollen development in Arabidopsis thaliana, produced by Aspergillus terreus . Zeitschrift für Naturforschung C. 57 . 5–6 . 459–464 . 2002 . 12132685 . 10.1515/znc-2002-5-610. 37714214 . free .
3. http://www.biocyc.org/META/NEW-IMAGE?type=COMPOUND-IN-PATHWAY&object=6-HYDROXYMELLEIN 6-Hydroxymellein biosynthesis pathway on www.biocyc.org