6-hydroxyhexanoate dehydrogenase explained

6-hydroxyhexanoate dehydrogenase
Ec Number:	1.1.1.258
Cas Number:	77000-03-4
Go Code:	0018463

In enzymology, a 6-hydroxyhexanoate dehydrogenase is an enzyme that catalyzes the chemical reaction

6-hydroxyhexanoate + NAD⁺

\rightleftharpoons 6-oxohexanoate + NADH + H⁺

Thus, the two substrates of this enzyme are 6-hydroxyhexanoate and NAD⁺, whereas its 3 products are 6-oxohexanoate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is 6-hydroxyhexanoate:NAD⁺ oxidoreductase. This enzyme participates in caprolactam degradation.

References

• Donoghue NA, Trudgill PW . 1975 . The metabolism of cyclohexanol by Acinetobacter NCIB 9871 . Eur. J. Biochem. . 60 . 1–7 . 1261 . 10.1111/j.1432-1033.1975.tb20968.x . 1 . free .
• Hecker LI, Tondeur Y, Farrelly JG . 1984 . Formation of epsilon-hydroxycaproate and epsilon-aminocaproate from N-nitrosohexamethyleneimine: evidence that microsomal alpha-hydroxylation of cyclic nitrosamines may not always involve the insertion of molecular oxygen into the substrate . Chem. Biol. Interact. . 49 . 235–48 . 6722936 . 10.1016/0009-2797(84)90064-4 . 1–2 .