6-Deoxy-5-ketofructose 1-phosphate synthase explained
| 6-deoxy-5-ketofructose 1-phosphate synthase |
| Ec Number: | 2.2.1.11 |
6-deoxy-5-ketofructose 1-phosphate synthase (DKFP synthase, MJ1585 (gene)) is an enzyme with systematic name 2-oxopropanal:D-fructose 1,6-bisphosphate glycerone-phosphotransferase.[1] [2] This enzyme catalyses the following chemical reaction
(1) methylglyoxal + D-fructose 1,6-bisphosphate
D-glyceraldehyde 3-phosphate + 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate
(2) methylglyoxal + D-fructose 1-phosphate
D-glyceraldehyde + 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate
This enzyme plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate.
Notes and References
- White RH, Xu H . Methylglyoxal is an intermediate in the biosynthesis of 6-deoxy-5-ketofructose-1-phosphate: a precursor for aromatic amino acid biosynthesis in Methanocaldococcus jannaschii . Biochemistry . 45 . 40 . 12366–79 . October 2006 . 17014089 . 10.1021/bi061018a .
- Samland AK, Wang M, Sprenger GA . MJ0400 from Methanocaldococcus jannaschii exhibits fructose-1,6-bisphosphate aldolase activity . FEMS Microbiology Letters . 281 . 1 . 36–41 . April 2008 . 18318840 . 10.1111/j.1574-6968.2008.01079.x . free .
