6-Methylapigenin Explained

6-Methylapigenin is a naturally occurring flavonoid and a derivative of apigenin. It has activity at GABAA receptors as a positive modulator.

Natural occurrence

6-Methylapigenin can be found in multiple plants, such as Valeriana officinalis, Valeriana jatamansi, and Picea neoveitchii.[1]

Biological activity

6-Methylapigenin binds to the GABAA receptor on the benzodiazepine binding site. This compound possesses anxiolytic effects. In a mouse model, it is also able to potentiate sleep induced by hesperidin, another flavonoid.[2] [3] However, since it does not have the chemical structure of benzodiazepines, it can therefore be classed as a nonbenzodiazepine.

Notes and References

  1. Web site: PubChem . 6-Methylapigenin . 2024-02-04 . pubchem.ncbi.nlm.nih.gov . en.
  2. Fernández . Sebastián P. . Wasowski . Cristina . Paladini . Alejandro C. . Marder . Mariel . 2005-04-11 . Synergistic interaction between hesperidin, a natural flavonoid, and diazepam . European Journal of Pharmacology . 512 . 2–3 . 189–198 . 10.1016/j.ejphar.2005.02.039 . 0014-2999 . 15840404.
  3. Marder . Mariel . Viola . Haydeé . Wasowski . Cristina . Fernández . Sebastián . Medina . Jorge H. . Paladini . Alejandro C. . 2003. 6-methylapigenin and hesperidin: new valeriana flavonoids with activity on the CNS . Pharmacology, Biochemistry, and Behavior . 75 . 3 . 537–545 . 10.1016/s0091-3057(03)00121-7 . 0091-3057 . 12895671. 37559366 .

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "6-Methylapigenin".

Except where otherwise indicated, Everything.Explained.Today is © Copyright 2009-2024, A B Cryer, All Rights Reserved. Cookie policy.