6-Hydroxymelatonin Explained

6-Hydroxymelatonin (6-OHM) is a naturally occurring, endogenous, major active metabolite of melatonin.^[1] Similar to melatonin, 6-OHM is a full agonist of the MT₁ and MT₂ receptors.^{[2] [3]} It is also an antioxidant and neuroprotective, and is even more potent in this regard relative to melatonin.^{[4] [5]}

See also

• N-Acetylserotonin (normelatonin)
• 5-Methoxytryptamine

Notes and References

1. Hardeland R . Melatonin metabolism in the central nervous system . Curr Neuropharmacol . 8 . 3 . 168–81 . 2010 . 21358968 . 3001211 . 10.2174/157015910792246164.
2. Dubocovich ML . Pharmacology and function of melatonin receptors . FASEB J. . 2 . 12 . 2765–73 . 1988 . 2842214 . 10.1096/fasebj.2.12.2842214. free . 45788574 .
3. Browning. Christopher. Beresford. Isabel. Fraser. Neil. Giles. Heather. Pharmacological characterization of human recombinant melatonin mt1and MT2receptors. British Journal of Pharmacology. 129. 5. 2000. 877–886. 0007-1188. 10.1038/sj.bjp.0703130. 10696085. 1571913.
4. Maharaj DS, Glass BD, Daya S . Melatonin: new places in therapy . Biosci. Rep. . 27 . 6 . 299–320 . 2007 . 17828452 . 10.1007/s10540-007-9052-1 . 32437175 .
5. Álvarez-Diduk R, Galano A, Tan DX, Reiter RJ . N-Acetylserotonin and 6-Hydroxymelatonin against Oxidative Stress: Implications for the Overall Protection Exerted by Melatonin . J Phys Chem B . 119. 27. 8535–43. 2015 . 26079042 . 10.1021/acs.jpcb.5b04920 . free .