6'-Deoxychalcone synthase explained

6'-Deoxychalcone synthase
Ec Number:	2.3.1.170
Cas Number:	114308-23-5

In enzymology, a 6'-deoxychalcone synthase is an enzyme that catalyzes the chemical reaction

3 malonyl-CoA + 4-coumaroyl-CoA + NADPH + H⁺

\rightleftharpoons 4 CoA + isoliquiritigenin + 3 CO₂ + NADP⁺ + H₂O

The 4 substrates of this enzyme are malonyl-CoA, 4-coumaroyl-CoA, NADPH, and H⁺, whereas its 5 products are CoA, isoliquiritigenin, CO₂, NADP⁺, and H₂O. Deoxychalcone synthase catalyzed activity is involved in the biosynthesis of retrochalcone and certain phytoalexins in the cells of Glycyrrhiza echinata (Russian licorice) and other leguminous plants.

This enzyme belongs to the family of transferases, to be specific those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing, reducing).

References

• Ayabe S, Udagawa A, Furuya T . 1988 . NAD(P)H-dependent 6'-deoxychalcone synthase activity in Glycyrrhiza echinata cells induced by yeast extract . Arch. Biochem. Biophys. . 261 . 458–62 . 3355160 . 10.1016/0003-9861(88)90362-1 . 2 .