6',7'-Dihydroxybergamottin Explained

6',7'-Dihydroxybergamottin is a natural furanocoumarin found in pomelos, grapefruits, and sour oranges,[1] in both the peel and the pulp. Along with the chemically related compound bergamottin, it is believed to be responsible for a number of grapefruit–drug interactions, in which the consumption of citrus containing one or both of these compounds (especially grapefruit) affects the metabolism of a variety of pharmaceutical drugs.[2] [3] [4]

Notes and References

  1. Dugrand-Judek . Audray . Olry . Alexandre . Hehn . Alain . Costantino . Gilles . Ollitrault . Patrick . Froelicher . Yann . Bourgaud . Frédéric . The Distribution of Coumarins and Furanocoumarins in Citrus Species Closely Matches Citrus Phylogeny and Reflects the Organization of Biosynthetic Pathways . PLOS ONE . November 2015 . 10 . 11 . e0142757 . 10.1371/journal.pone.0142757 . 26558757 . 4641707. 2015PLoSO..1042757D . free .
  2. Edwards . D. J. . Bellevue . F. H. . Woster . P. M. . Identification of 6',7'-dihydroxybergamottin, a cytochrome P450 inhibitor, in grapefruit juice . Drug Metabolism and Disposition . December 1996 . 24 . 12 . 1287–1290 . 8971132 .
  3. Bailey . David G. . Malcolm . J. . Arnold . O. . Spence . J. David . Grapefruit juice-drug interactions . Br J Clin Pharmacol . 1998 . 46 . 2 . 101–110 . 10.1046/j.1365-2125.1998.00764.x . 9723817 . 1873672.
  4. Girennavar . Basavaraj . Poulose . Shibu M. . Jayaprakasha . Guddadarangavvanahally K. . Bhat . Narayan G. . Patil . Bhimanagouda S. . Furocoumarins from grapefruit juice and their effect on human CYP 3A4 and CYP 1B1 isoenzymes . Bioorganic & Medicinal Chemistry . 2006 . 14 . 8 . 2606–2612 . 0968-0896 . 10.1016/j.bmc.2005.11.039 . 16338240.

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