6'''-Hydroxyneomycin C oxidase explained

6-hydroxyneomycin C oxidase| EC_number = 1.1.3.44| CAS_number =| GO_code = | image = | width = | caption = }}6-hydroxyneomycin C oxidase (neoG (gene)) is an enzyme with systematic name 6-deamino-6-hydroxyneomycin C:oxygen 6-oxidoreductase.^[1] ^[2] This enzyme catalyses the following chemical reaction

6-deamino-6-hydroxyneomycin C + O₂

\rightleftharpoons

6-deamino-6-oxoneomycin C + H₂O₂

This enzyme participates in biosynthesis of aminoglycoside antibiotics of the neomycin family.

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Notes and References

Huang F, Spiteller D, Koorbanally NA, Li Y, Llewellyn NM, Spencer JB . Elaboration of neosamine rings in the biosynthesis of neomycin and butirosin . ChemBioChem . 8 . 3 . 283–8 . February 2007 . 17206729 . 10.1002/cbic.200600371 .
Clausnitzer D, Piepersberg W, Wehmeier UF . The oxidoreductases LivQ and NeoQ are responsible for the different 6'-modifications in the aminoglycosides lividomycin and neomycin . Journal of Applied Microbiology . 111 . 3 . 642–51 . September 2011 . 21689223 . 10.1111/j.1365-2672.2011.05082.x . free .