| Unit Name: | 5th Guards Grenadiers |
| Native Name: | Garde-Grenadier-Regiment Nr. 5 |
| Start Date: | 31 March 1897 |
| End Date: | 12 December 1918 |
| Country: | German Empire |
| Allegiance: | Kingdom of Prussia |
| Branch: | Infantry |
| Type: | Grenadiers |
| Command Structure: | Guards Corps |
| Garrison: | Spandau |
| Nickname: | Briefträger (post men) |
| Colours: | --> |
| Colours Label: | --> |
| Disbanded: | 12 December 1918 |
| Commander2: | Grand Duke Konstantin Konstantinovich of Russia |
| Notable Commanders: |
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The 5th Guard Grenadiers (German: Garde-Grenadier-Regiment Nr. 5) was a regiment of the Prussian Army prior to and during the First World War. Established in 1897, it was part of the 5th Guard Infantry Brigade. The regiment was disbanded following the war and perpetuated by 5th and 6th Company, 4th Infantry Regiment of the Reichswehr.