5F-PCN explained

5F-PCN (also known as 5F-MN-21) is an azaindole-based synthetic cannabinoid that is presumed to be a potent agonist of the CB₁ receptor and has been sold online as a designer drug.^{[1] [2]} It is closely related to NNE1. Given the known metabolic liberation (and presence as an impurity) of amantadine in the related compound APINACA, it is suspected that metabolic hydrolysis of the amide group of 5F-PCN may release 1-naphthylamine, a known carcinogen.

Legal status

Sweden's public health agency suggested to classify 5F-PCN as hazardous substance on November 10, 2014.^[3]

See also

• 5F-NNE1
• AM-2201
• APICA
• CUMYL-PICA
• CUMYL-5F-P7AICA
• JWH-018
• NM-2201
• SDB-005

Notes and References

1. Web site: 5F-PCN . Cayman Chemical . 22 July 2015.
2. Blaazer AR, Lange JH, van der Neut MA, Mulder A, den Boon FS, Werkman TR, Kruse CG, Wadman WJ . 6 . Novel indole and azaindole (pyrrolopyridine) cannabinoid (CB) receptor agonists: design, synthesis, structure-activity relationships, physicochemical properties and biological activity . European Journal of Medicinal Chemistry . 46 . 10 . 5086–98 . October 2011 . 21885167 . 10.1016/j.ejmech.2011.08.021 .
3. Web site: Cannabinoider föreslås bli klassade som hälsofarlig vara . Folkhälsomyndigheten . 22 July 2015.