5F-PB-22 explained

5F-PB-22 (5F-QUPIC or quinolin-8-yl 1-pentyfluoro-1H-indole-3-8-carboxylate) is a designer drug which acts as a cannabinoid agonist.^[1] The structure of 5F-PB-22 appears to have been designed with an understanding of structure–activity relationships within the indole class of cannabinoids.^[2]

Pharmacology

5F-PB-22 acts as a full agonist with a binding affinity of 0.468 nM at CB₁ and 0.633 nM at CB₂ cannabinoid receptors.^[3]

Legal status

As of October 2015 5F-PB-22 is a controlled substance in China.^[4]

In January 2014, 5F-PB-22 was designated as a Schedule I controlled substance in the United States after several deaths were associated with its use.^{[5] [6]}

In the United Kingdom, 5F-PB-22 is now classified and controlled as a Class B drug, following the November 2016 amendment to the Misuse of Drugs Act 1971. Several other synthetic cannabinoids structurally related to JWH-018, like 5F-PB-22, were also classified in this amendment.^[7]

See also

• AM-2201
• JWH-018
• QUCHIC
• QUPIC
• SDB-001
• SDB-005

Notes and References

1. Banister SD, Stuart J, Kevin RC, Edington A, Longworth M, Wilkinson SM, Beinat C, Buchanan AS, Hibbs DE, Glass M, Connor M, McGregor IS, Kassiou M . 6 . Effects of bioisosteric fluorine in synthetic cannabinoid designer drugs JWH-018, AM-2201, UR-144, XLR-11, PB-22, 5F-PB-22, APICA, and STS-135 . ACS Chemical Neuroscience . 6 . 8 . 1445–58 . August 2015 . 25921407 . 10.1021/acschemneuro.5b00107 .
2. Web site: 5F-PB-22 . Forendex . 24 June 2015 . https://web.archive.org/web/20150927173624/http://forendex.southernforensic.org/index.php/detail/index/1233 . 27 September 2015 . dead . dmy-all .
3. Hess C, Schoeder CT, Pillaiyar T, Madea B, Müller CE . Pharmacological evaluation of synthetic cannabinoids identified as constituents of spice . Forensic Toxicology . 34 . 2 . 329–343 . 1 July 2016 . 27429655 . 4929166 . 10.1007/s11419-016-0320-2 .
4. Web site: 关于印发《非药用类麻醉药品和精神药品列管办法》的通知 . China Food and Drug Administration . 27 September 2015 . Chinese . 1 October 2015 . https://web.archive.org/web/20151001222554/http://www.sfda.gov.cn/WS01/CL0056/130753.html . 1 October 2015 . dead .
5. Behonick G, Shanks KG, Firchau DJ, Mathur G, Lynch CF, Nashelsky M, Jaskierny DJ, Meroueh C . 6 . Four postmortem case reports with quantitative detection of the synthetic cannabinoid, 5F-PB-22 . Journal of Analytical Toxicology . 38 . 8 . 559–62 . October 2014 . 24876364 . 4334789 . 10.1093/jat/bku048 .
6. Trecki J, Gerona RR, Schwartz MD . Synthetic Cannabinoid-Related Illnesses and Deaths . The New England Journal of Medicine . 373 . 2 . 103–7 . July 2015 . 26154784 . 10.1056/NEJMp1505328 .
7. Web site: The Misuse of Drugs Act 1971 (Amendment) Order 2016. www.legislation.gov.uk. en. 2017-12-20.