5F-NNE1 explained

5F-NNE1 (also known as 5F-NNEI and 5F-MN-24) is an indole-based synthetic cannabinoid that is presumed to be a potent agonist of the CB1 receptor and has been sold online as a designer drug.[1] [2] Given the known metabolic liberation (and presence as an impurity) of amantadine in the related compound APINACA, it is suspected that metabolic hydrolysis of the amide group of 5F-NNE1 may release 1-naphthylamine, a known carcinogen.

Legality

Sweden's public health agency suggested classifying 5F-NNE1 as hazardous substance on November 10, 2014.[3]

See also

Notes and References

  1. Web site: 5F-NNEI . Southern Association of Forensic Scientists . 24 July 2015 . https://web.archive.org/web/20150527205851/http://forendex.southernforensic.org/index.php/detail/index/1237 . 27 May 2015 . dead . dmy-all .
  2. Wohlfarth A, Castaneto MS, Zhu M, Pang S, Scheidweiler KB, Kronstrand R, Huestis MA . Pentylindole/Pentylindazole Synthetic Cannabinoids and Their 5-Fluoro Analogs Produce Different Primary Metabolites: Metabolite Profiling for AB-PINACA and 5F-AB-PINACA . The AAPS Journal . 17 . 3 . 660–77 . May 2015 . 25721194 . 4406957 . 10.1208/s12248-015-9721-0 .
  3. Web site: Cannabinoider föreslås bli klassade som hälsofarlig vara . Folkhälsomyndigheten . 24 July 2015.

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