5F-ADB-PINACA explained

5F-ADB-PINACA is a cannabinoid designer drug that is an ingredient in some synthetic cannabis products. It is a potent agonist of the CB₁ receptor and CB₂ receptor with EC₅₀ values of 0.24 nM and 2.1 nM respectively.^{[1] [2]}

Metabolism

Twelve 5F-ADB-PINACA major metabolites were identified in several incubations with cryopreserved human hepatocytes. Major metabolic reactions included oxidative defluorination followed by carboxylation.^[3]

Legality

5F-ADB-PINACA is listed in the Fifth Schedule of the Misuse of Drugs Act (MDA) and therefore illegal in Singapore as of May 2015.^[4]

See also

• 5F-AB-PINACA
• 5F-ADB
• 5F-AMB
• 5F-APINACA
• AB-FUBINACA
• AB-CHFUPYCA
• AB-CHMINACA
• AB-PINACA
• ADB-CHMINACA
• ADB-FUBINACA
• ADB-PINACA
• ADBICA
• APICA
• APINACA
• APP-FUBINACA
• MDMB-CHMICA
• MDMB-CHMINACA
• MDMB-FUBINACA
• PX-1
• PX-2
• PX-3

Notes and References

1. Banister SD, Moir M, Stuart J, Kevin RC, Wood KE, Longworth M, Wilkinson SM, Beinat C, Buchanan AS, Glass M, Connor M, McGregor IS, Kassiou M . 6 . Pharmacology of Indole and Indazole Synthetic Cannabinoid Designer Drugs AB-FUBINACA, ADB-FUBINACA, AB-PINACA, ADB-PINACA, 5F-AB-PINACA, 5F-ADB-PINACA, ADBICA, and 5F-ADBICA . ACS Chemical Neuroscience . 6 . 9 . 1546–59 . September 2015 . 26134475 . 10.1021/acschemneuro.5b00112 .
2. Web site: 5F-ADB-PINACA . Cayman Chemical.
3. Carlier J, Diao X, Scheidweiler KB, Huestis MA . Distinguishing Intake of New Synthetic Cannabinoids ADB-PINACA and 5F-ADB-PINACA with Human Hepatocyte Metabolites and High-Resolution Mass Spectrometry . Clinical Chemistry . 63 . 5 . 1008–1021 . May 2017 . 28302730 . 10.1373/clinchem.2016.267575 . free .
4. Web site: CNB NEWS RELEASE . Central Narcotics Bureau (CNB) . 30 April 2015 . 24 July 2015 . https://web.archive.org/web/20150715045305/http://www.cnb.gov.sg/Libraries/CNB_Newsroom_Files/CNB_NR_-_30_Apr_2015.sflb.ashx . 15 July 2015 . dead .