5F-AB-FUPPYCA explained

5F-AB-FUPPYCA (also known as AZ-037) is a pyrazole-based synthetic cannabinoid that is presumed to be an agonist of the CB₁ receptor and has been sold online as a designer drug.^{[1] [2]} It was first detected by the EMCDDA as part of a seizure of 540 g white powder in France in February 2015.^[3]

The name AZ-037 is also used as a synonym for its structural isomer 5-fluoro-3,5-AB-PFUPPYCA.^[4] Thus AZ-037 is being used as a synonym for two different compounds.

5-fluoro-3,5-AB-PFUPPYCA has been detected in synthetic cannabinoid smoke blends in the USA as early as December 30, 2021, along with ADB-BUTINACA, MDA-19 (BZO-HEXOXIZID) and MDMB-4en-PINACA.^[5]

5-fluoro-AB-PFUPPYCA contains some similar structural elements to other synthetic cannabinoids such as AB-CHFUPYCA, JWH-307, JWH-030, JWH-147, AB-PINACA. It may be considered an analog of the traditional pyrazole cannabinoid receptor 1 antagonist rimonabant. The pharmacological properties of 5F-AB-FUPPYCA have not been studied.

Legality

In the United States, 5F-AB-FUPPYCA is unscheduled at the federal level as of May 22, 2023. It's possible that it may be considered under the federal analogue act as a functional analog due to pharmacology or as a distant structural analog of JWH-307.

North Dakota has placed 5F-AB-FUPPYCA (N-(1-carbamoyl-2-methyl-propyl)-2-(5-fluoropentyl)-5-(4-fluorophenyl)pyrazole-3-carboxamide) into Schedule I status on 04/27/2023. However, this did not include structural substitutions it gave to other cannabinoid structural classes. As such does not include other pyrazoles analogs such as the non-fluorinated AB-FUPPYCA analog.^[6]

See also

• AB-CHFUPYCA
• AM-6545
• TM-38837
• Rimonabant
• JWH-307
• JWH-147
• JWH-030
• AB-FUBINACA
• ADB-FUBINACA
• AMB-FUBINACA
• APP-FUBINACA
• MDA-19
• FUB-144
• FUB-APINACA
• FUB-JWH-018
• FDU-PB-22
• FUB-PB-22
• MDMB-FUBICA
• MDMB-FUBINACA

Notes and References

1. Girreser U, Rösner P, Vasilev A . Structure elucidation of the designer drug N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1-(5-fluoropentyl)-3-(4-fluorophenyl)-pyrazole-5-carboxamide and the relevance of predicted (13) C NMR shifts - a case study . Drug Testing and Analysis . 8 . 7 . 668–75 . July 2016 . 26012418 . 10.1002/dta.1820 .
2. Banister SD, Longworth M, Kevin R, Sachdev S, Santiago M, Stuart J, Mack JB, Glass M, McGregor IS, Connor M, Kassiou M . 6 . Pharmacology of Valinate and tert-Leucinate Synthetic Cannabinoids 5F-AMBICA, 5F-AMB, 5F-ADB, AMB-FUBINACA, MDMB-FUBINACA, MDMB-CHMICA, and Their Analogues . ACS Chemical Neuroscience . 7 . 9 . 1241–54 . September 2016 . 27421060 . 10.1021/acschemneuro.6b00137 .
3. Web site: 2015. ÉVI EURÓPAI KÁBÍTÓSZER - JELENTÉS - A MONITOROZÁS 20 ÉVE . Hungarian National Focal Point (NFP) . June 2015 . 23 July 2015 . 24 July 2015 . https://web.archive.org/web/20150724022838/http://drogfokuszpont.hu/wp-content/uploads/NFP_hirlevel_2015_junius.pdf . live .
4. Web site: 5-fluoro-3,5-AB-PFUPPYCA . Cayman Chemical Company . 11 February 2016 . 3 June 2016 . https://web.archive.org/web/20160603030151/https://www.caymanchem.com/product/17181 . live .
5. Web site: Test Details : Result #11908 - Plant Material, 11908 . DrugsData.org (was EcstasyData) . 2022-04-17 . 2022-04-16 . https://web.archive.org/web/20220416034503/https://drugsdata.org/view.php?id=11908 . live .
6. Web site: AN ACT to amend and reenact sections 19-03.1-05, 19-03.1-11, and 19-03.1-13 of the North Dakota Century Code, relating to the scheduling of controlled substances; and to declare an emergency. . Sixty-eighth Legislative Assembly of North Dakota in Regular Session . 3 January 2023 .