5Beta-Scymnol Explained

5Beta-Scymnol, also known simply as scymnol, is a synthetic INCI-listed skin conditioning ingredient.^{[1] [2] [3]} The molecule is a steroid derivative that behaves as a hydroxyl radical scavenger and is used for the treatment of skin blemishes such as blocked pores and acne.^[4]

History

The molecule was identified and isolated from shark tissues by Professor Takuo Kosuge, Shizuoka College of Pharmacy, Shizuoka, Japan during the 1980s. Based on usage as a traditional folk remedy, it was hypothesised the ingredient may be effective for the treatment of scalds, blemishes and acne.^{[5] [6] [7]}

Traits

5Beta-Scymnol is a hydroxyl (OH) free radical scavenger.^[8] Scymnol's role in quenching free radicals may play a role in inhibiting acne.^{[7] [9]}

Notes and References

1. Web site: INCI. Personal Care Products Council.
2. Web site: SODIUM SCYMNOL SULFATE - Ingrédient INCI Beauty . 2022-05-30 . incibeauty.com.
3. Dunlop . K.J. . Barnetson . R.S. . February 1995 . A comparative study of isolutrol versus benzoyl peroxide in the treatment of acne . The Australasian Journal of Dermatology . 36 . 1 . 13–15 . 10.1111/j.1440-0960.1995.tb00917.x . 0004-8380 . 7763215. 23139723 .
4. Book: Chaston, Ian . Technological Entrepreneurship: Technology-Driven vs Market-Driven Innovation . 2017-01-28 . Springer . 978-3-319-45850-2 . en.
5. Kosuge, Y., Kosuge, T., Tsuji, K., Ishida, H., and Broadbent, J. M. (1989). Scymnol sulphate salts isolated from shark tissues for the treatment of liver and skin ailments (Patent: PCTInt Appl. WO 8801274-C.I. CO7J31/ 00). Chem. Abslr. 110, 88640g
6. Muthusamy . Visalini . Hodges . Lynn D. . Macrides . Theodore A. . Boyle . Glen M. . Piva . Terrence J. . 2011 . Effect of Novel Marine Nutraceuticals on IL-1α-Mediated TNF-α Release from UVB-Irradiated Human Melanocyte-Derived Cells . Oxidative Medicine and Cellular Longevity . 2011 . 728645 . 10.1155/2011/728645 . 1942-0900 . 3179886 . 21961050. free .
7. Guardiola-Griffiths . Cristina . 2011-09-01 . Medieval mean girls: on sexual rivalry and the uses of cosmetics in La Celestina . EHumanista . English . 19 . 172–193.
8. Macrides et al, A comparison of the hydroxyl radical scavenging properties of the shark bile steroid 5β-scymnol and plant pycnogenols, Biochem Mol Biol Int. 1997 Sep;42(6):1249-60
9. 3179074 . 2011 . Zasloff . M. . Adams . A. P. . Beckerman . B. . Campbell . A. . Han . Z. . Luijten . E. . Meza . I. . Julander . J. . Mishra . A. . Qu . W. . Taylor . J. M. . Weaver . S. C. . Wong . G. C. . Squalamine as a broad-spectrum systemic antiviral agent with therapeutic potential . Proceedings of the National Academy of Sciences of the United States of America . 108 . 38 . 15978–15983 . 10.1073/pnas.1108558108 . 21930925 . 2011PNAS..10815978Z . free .