5-hydroxyfuranocoumarin 5-O-methyltransferase explained
| 5-hydroxyfuranocoumarin 5-O-methyltransferase |
| Ec Number: | 2.1.1.69 |
| Cas Number: | 67339-12-2, 101637-31-4 |
5-hydroxyfuranocoumarin 5-O-methyltransferase (furanocoumarin 5-methyltransferase, furanocoumarin 5-O-methyltransferase, bergaptol 5-O-methyltransferase, bergaptol O-methyltransferase, bergaptol methyltransferase, S-adenosyl-L-methionine:bergaptol O-methyltransferase, BMT, S-adenosyl-L-methionine:5-hydroxyfuranocoumarin 5.1-O-methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:5-hydroxyfurocoumarin 5-O-methyltransferase.[1] [2] [3] [4] This enzyme catalyses the following chemical reaction
(1) S-adenosyl-L-methionine + a 5-hydroxyfurocoumarin
S-adenosyl-L-homocysteine + a 5-methoxyfurocoumarin (general reaction)
S-adenosyl-L-homocysteine +
bergaptenThe enzyme methylates the 5-hydroxy group of some hydroxy- and methylcoumarins, such as 5-hydroxyxanthotoxin.
Notes and References
- Thompson HJ, Sharma SK, Brown SA . O-methyltransferases of furanocoumarin biosynthesis . Archives of Biochemistry and Biophysics . 188 . 2 . 272–81 . June 1978 . 28084 . 10.1016/s0003-9861(78)80009-5 .
- Sharma SK, Garrett JM, Brown SA . Separation of the S-adenosylmethionine: 5- and 8-hydroxyfuranocoumarin O-methyltransferases of Ruta graveolens L. by general ligand affinity chromatography . Zeitschrift für Naturforschung C . 34C . 5–6 . 387–91 . 1979 . 156999 . 10.1515/znc-1979-5-611 . free .
- Elicitor-stimulated furanocoumarin biosynthesis in cultured parsley cells - S-adenosyl-L-methionine-bergaptol and S-adenosyl-L-methionine-xanthotoxol O-methyltransferases . Hauffe, K.D. . Hahlbrock, K. . Scheel, D. . Zeitschrift für Naturforschung C . 1986 . 41 . 228–239 . 10.1515/znc-1986-1-234 . free .
- Hehmann M, Lukacin R, Ekiert H, Matern U . Furanocoumarin biosynthesis in Ammi majus L. Cloning of bergaptol O-methyltransferase . European Journal of Biochemistry . 271 . 5 . 932–40 . March 2004 . 15009205 . 10.1111/j.1432-1033.2004.03995.x .
