5-TFM-DMT explained

5-TFM-DMT (5-(trifluoromethyl)-DMT, 5-CF3-DMT, 5-(trifluoromethyl)-N,N-dimethyltryptamine) is a putative psychedelic tryptamine derivative related to drugs such as 5-MeO-DMT, 5-Fluoro-DMT, and 5-TFMO-DMT. It acts as a partial agonist at the 5-HT_2A receptor, with an EC₅₀ of 185.7 nM and an efficacy of 28.7% (vs 5-HT), and a full agonist at 5-HT_2C with an EC₅₀ of 89.7 nM and an efficacy of 88.8%, and no significant activity at 5-HT_2B.^[1]

See also

• 5-MeO-DMT
• 5-Bromo-DMT
• 5-Chloro-DMT
• 5-Fluoro-DMT
• 5-Nitro-DMT
• 5-TFMO-DMT

Notes and References

1. https://patentscope.wipo.int/search/docs2/pct/WO2023115167/pdf/uTsfnwYKKU3GP3xLdE_D0L1ARzXZ9KhmF7OoIanI51o?filename=WO2023115167-PAMPH-20230629-9042.pdf Banister S, Jorgensen W, Jinlong T. Compounds. Patent WO 2023/115167