5-MeO-DiBF explained

5-MeO-DiBF is a psychedelic^[1] that has been sold online as a designer drug and was first definitively identified in December 2015 by a forensic laboratory in Slovenia.^[2] It is thought to act as an agonist for the 5-HT_1A and 5-HT₂ family of serotonin receptors. It is related in structure to the psychedelic tryptamine derivative 5-MeO-DiPT, but with the indole nitrogen replaced by oxygen, making 5-MeO-DiBF a benzofuran derivative. It is several times less potent as a serotonin agonist than 5-MeO-DiPT and with relatively more activity at 5-HT_1A, but still shows strongest effects at the 5-HT₂ family of receptors.^{[3] [4]}

Legal status

5-MeO-DiBF is not controlled under the 1971 Convention on Psychotropic Substances, so thus it has a legal grey area in many countries, but it's possible it could be illegal under so-called analogue acts if sold for human consumption.

See also

• Dimemebfe

Notes and References

1. Casale JF, Hays PA . The Characterization of 2-(5-Methoxy-1-benzofuran-3-yl)-N,N-dimethylethanamine (5-MeO-BFE) and Differentiation from its N-Ethyl Analog . Microgram Journal . 9 . 1 . 39–45 .
2. Web site: Europol 2015 Annual Report on the implementation of Council Decision 2005/387/JHA . European Monitoring Center for Drugs and Drug Addiction .
3. Tomaszewski Z, Johnson MP, Huang X, Nichols DE . Benzofuran bioisosteres of hallucinogenic tryptamines . Journal of Medicinal Chemistry . 35 . 11 . 2061–4 . May 1992 . 1534585 . 10.1021/jm00089a017 .
4. McKenna DJ, Repke DB, Lo L, Peroutka SJ . Differential interactions of indolealkylamines with 5-hydroxytryptamine receptor subtypes . Neuropharmacology . 29 . 3 . 193–8 . March 1990 . 2139186 . 10.1016/0028-3908(90)90001-8 . 24188017 . free .