5-MeO-DET explained

5-MeO-DET or 5-methoxy-N,N-diethyltryptamine is a hallucinogenic tryptamine.

Pharmacology

5-MeO-DET inhibits serotonin reuptake with an IC₅₀ value of 2.4 μM and activates 5-HT_2A receptors with an EC₅₀ value of 8.11 nM.^{[1] [2] [3] [4] [5] [6] [7]}

Effects

Low dosages (0.5–1 mg) are reported to produce a relaxing body high and mild entheogenic effects. Shulgin reports in TiHKAL that higher dosages (1–3 mg) can produce very unpleasant reactions.

See also

• 5-MeO-DiPT
• 5-MeO-DMT
• 5-MeO-MiPT
• TiHKAL

External links

• TiHKAL entry #36
• 5-MeO-DET entry in TiHKAL • info

Notes and References

1. Quasi-atomistic Receptor Surrogates for the 5-HT_2A Receptor: A 3D-QSAR Study on Hallucinogenic Substances . Schulze-Alexandru M, Kovar KA, Vedani A . Quantitative Structure-Activity Relationships . December 1999 . 18 . 6 . 548–560 . 10.1002/(SICI)1521-3838(199912)18:6<548::AID-QSAR548>3.0.CO;2-B. 10.1.1.669.1877.
2. Gatch MB, Forster MJ, Janowsky A, Eshleman AJ . Abuse liability profile of three substituted tryptamines . The Journal of Pharmacology and Experimental Therapeutics . 338 . 1 . 280–9 . July 2011 . 21474568 . 3126641 . 10.1124/jpet.111.179705 .
3. Glennon RA, Gessner PK . Serotonin receptor binding affinities of tryptamine analogues . Journal of Medicinal Chemistry . 22 . 4 . 428–32 . April 1979 . 430481 . 10.1021/jm00190a014 .
4. Halberstadt AL, Geyer MA . Multiple receptors contribute to the behavioral effects of indoleamine hallucinogens . Neuropharmacology . 61 . 3 . 364–81 . September 2011 . 21256140 . 3110631 . 10.1016/j.neuropharm.2011.01.017 .
5. Gessner PK, Godse DD, Krull AH, McMullan JM . Structure-activity relationships among 5-methoxy-n:n-dimethyltryptamine, 4-hydroxy-n:n-dimethyltryptamine (psilocin) and other substituted tryptamines . Life Sciences . 7 . 5 . 267–77 . March 1968 . 5641719 . 10.1016/0024-3205(68)90200-2 .
6. Lyon RA, Titeler M, Seggel MR, Glennon RA . Indolealkylamine analogs share 5-HT2 binding characteristics with phenylalkylamine hallucinogens . European Journal of Pharmacology . 145 . 3 . 291–7 . January 1988 . 3350047 . 10.1016/0014-2999(88)90432-3 .
7. Blough BE, Landavazo A, Decker AM, Partilla JS, Baumann MH, Rothman RB . Interaction of psychoactive tryptamines with biogenic amine transporters and serotonin receptor subtypes . Psychopharmacology . 231 . 21 . 4135–44 . October 2014 . 24800892 . 4194234 . 10.1007/s00213-014-3557-7 .