5-Hydroxyuracil Explained

5-Hydroxyuracil is an oxidized form of cytosine that is produced by the oxidative deamination of cytosines by reactive oxygen species.[1] It does not distort the DNA molecule and is bypassed by replicative DNA polymerases. It can miscode for adenine and is potentially mutagenic.[2]

Notes and References

  1. 5-Hydroxyuracil can form stable base pairs with all four bases in a DNA duplex. Varatharasa Thiviyanathan. Anoma Somasunderam. David E. Volka. David G. Gorenstein. amp . Chem. Commun. . 3. 2005 . 400–402 . 10.1039/B414474K. 15645051.
  2. Book: The Cellular Response to the Genotoxic Insult: The Question of Threshold for Genotoxic Carcinogens . Helmut Greim . Richard J. Albertini . Royal Society of Chemistry . 2012 . July 20, 2015. 9781849731775 .

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