5-HO-DiPT explained

5-HO-DiPT (5-hydroxy-N,N-di-iso-propyltryptamine) is a tryptamine derivative which acts as a serotonin receptor agonist. It is primarily known as a metabolite of the better known psychoactive drug 5-MeO-DiPT,[1] but 5-HO-DiPT has also rarely been encountered as a designer drug in its own right.[2] Tests in vitro show 5-HO-DiPT to have high 5-HT2A affinity and good selectivity over 5-HT1A,[3] while being more lipophilic than the related drug bufotenine (5-HO-DMT), which produces mainly peripheral effects.

See also

Notes and References

  1. Yu AM . Indolealkylamines: biotransformations and potential drug-drug interactions . The AAPS Journal . 10 . 2 . 242–53 . June 2008 . 18454322 . 2751378 . 10.1208/s12248-008-9028-5 .
  2. Brandt SD, Martins CU . 10.1016/j.trac.2010.04.008 . Analytical methods for psychoactive N,N-dialkylated tryptamines . TrAC Trends in Analytical Chemistry . 29 . 8 . 858–869 . 2010 .
  3. McKenna DJ, Repke DB, Lo L, Peroutka SJ . Differential interactions of indolealkylamines with 5-hydroxytryptamine receptor subtypes . Neuropharmacology . 29 . 3 . 193–8 . March 1990 . 2139186 . 10.1016/0028-3908(90)90001-8 . 24188017 . free .

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