5-Formyluracil Explained

5-Formyluracil is a heterocyclic organic base. It is produced from the oxidation of the methyl group of thymine. It is found in bacteriophages, prokaryotes, as well as mammalian cells. Being mutagenic, it is of particular interest in the field of epigenetics.^[1] It has been implicated in the formation of cancer causing cells.^[2]

Notes and References

1. 5-Formyluracil and its nucleoside derivatives confer toxicity and mutagenicity to mammalian cells by interfering with normal RNA and DNA metabolism. 11275423 . 119 . Toxicol Lett . 71–8 . Klungland . A . Paulsen . R . Rolseth . V . Yamada . Y . Ueno . Y . Wiik . P . Matsuda . A . Seeberg . E . Bjelland . S . 2001 . 1 . 10.1016/s0378-4274(00)00308-8.
2. Wang. Yafen. Zhang. Xiong. Zou. Guangrong. Peng. Shuang. Liu. Chaoxing. Zhou. Xiang. 2019-04-16. Detection and Application of 5-Formylcytosine and 5-Formyluracil in DNA. Accounts of Chemical Research. 52. 4. 1016–1024. 10.1021/acs.accounts.8b00543. 30666870 . 58623597 . 0001-4842.