5-Fluoro-AMT explained

5-Fluoro-α-methyltryptamine (5-Fluoro-αMT, 5F-AMT), also known as PAL-544,^[1] is a putative stimulant, entactogen, and psychedelic tryptamine derivative related to α-methyltryptamine (αMT). It has been found to act as a well-balanced serotonin-norepinephrine-dopamine releasing agent,^[1] a 5-HT_2A receptor agonist,^[2] and a potent and specific MAO-A inhibitor.^{[3] [4] [5] [6]} which suggests that 5-fluoro-αMT could be an active psychedelic in humans, although it is not known to have been tested in humans and could be dangerous due to its strong inhibition of MAO-A.

See also

• 5-Chloro-αMT
• 5-Fluoro-AET
• 5-Fluoro-DMT
• 6-Fluoro-AMT
• 7-Chloro-AMT
• 7-Methyl-αET
• Flucindole
• 5-API (PAL-571)

Further reading

• Nakagawasai O, Arai Y, Satoh SE, Satoh N, Neda M, Hozumi M, Oka R, Hiraga H, Tadano T . 6 . Monoamine oxidase and head-twitch response in mice. Mechanisms of alpha-methylated substrate derivatives . Neurotoxicology . 25 . 1–2 . 223–32 . January 2004 . 14697897 . 10.1016/S0161-813X(03)00101-3 .

Notes and References

1. Banks ML, Bauer CT, Blough BE, Rothman RB, Partilla JS, Baumann MH, Negus SS . Abuse-related effects of dual dopamine/serotonin releasers with varying potency to release norepinephrine in male rats and rhesus monkeys . Experimental and Clinical Psychopharmacology . 22 . 3 . 274–284 . June 2014 . 24796848 . 4067459 . 10.1037/a0036595 .
2. Chairungsrilerd N, Furukawa K, Tadano T, Kisara K, Ohizumi Y . Effect of gamma-mangostin through the inhibition of 5-hydroxy-tryptamine2A receptors in 5-fluoro-alpha-methyltryptamine-induced head-twitch responses of mice . British Journal of Pharmacology . 123 . 5 . 855–62 . March 1998 . 9535013 . 1565246 . 10.1038/sj.bjp.0701695 .
3. Kinemuchi H, Arai Y . Selective inhibition of monoamine oxidase A and B by two substrate-analogues, 5-fluoro-alpha-methyltryptamine and p-chloro-beta-methylphenethylamine . Research Communications in Chemical Pathology and Pharmacology . 54 . 1 . 125–8 . October 1986 . 3797802 . 10.1016/0028-3908(91)90057-i . 34761939 .
4. Kim SK, Toyoshima Y, Arai Y, Kinemuchi H, Tadano T, Oyama K, Satoh N, Kisara K . 6 . Inhibition of monoamine oxidase by two substrate-analogues, with different preferences for 5-hydroxytryptamine neurons . Neuropharmacology . 30 . 4 . 329–35 . April 1991 . 1852266 . 10.1016/0028-3908(91)90057-i . 34761939 .
5. Corne SJ, Pickering RW . A possible correlation between drug-induced hallucinations in man and a behavioural response in mice . Psychopharmacologia . 11 . 1 . 65–78 . 1967 . 5302272 . 10.1007/bf00401509 . 3148623 .
6. Yamamoto T, Ueki S . The role of central serotonergic mechanisms on head-twitch and backward locomotion induced by hallucinogenic drugs . Pharmacology, Biochemistry, and Behavior . 14 . 1 . 89–95 . January 1981 . 6258178 . 10.1016/0091-3057(81)90108-8 . 45561708 .