5-EAPB explained

5-EAPB (1-(benzofuran-5-yl)-N-ethylpropan-2-amine) is a potentially entactogenic amphetamine which is structurally related to 5-MAPB and 5-APB. It might be predicted to show similar effects to these drugs in humans, but the pharmacology of 5-EAPB remains unstudied as of 2020.

5-EAPB is similar in structure to compounds such as 5-APB which are claimed to be agonists of the 5-HT_2C receptor^[1] as well as a triple monoamine reuptake inhibitor, however 5-EAPB is not listed as an example in this patent, and it is not yet established to what extent the activity of 5-EAPB resembles that of 5-APB.

Legality

In the UK, all benzofurans are considered Class B drugs^[2] and are therefore illegal.

5-EAPB is listed in the Fifth Schedule of the Misuse of Drugs Act (MDA) and therefore illegal in Singapore as of May 2015.^[3]

Adverse reactions and deaths

Three people in their 30s were hospitalised after each taking approximately 500 mg of 5-EAPB, one of whom later died in hospital, whilst attending Brownstock music festival in Essex, UK on August 31, 2013.^[4]

Notes and References

1. US . 7045545 . patent . Aminoalkylbenzofurans as serotonin (5-HT(2c)) agonists . 2000-01-19 . 2006-16-03 . Briner K, Burkhart P, Burkholder P, Fisher MJ, Gritton WH, Kohlman DT, Liang SX, Miller SC, Mullaney JT, Xu YX . Eli Lilly and Co .
2. Web site: 10 June 2014 . Ban on NBOMe and benzofurans comes into force . Gov.uk .
3. Web site: CNB NEWS RELEASE . Central Narcotics Bureau (CNB) . 30 April 2015 . 24 July 2015 . https://web.archive.org/web/20150715045305/http://www.cnb.gov.sg/Libraries/CNB_Newsroom_Files/CNB_NR_-_30_Apr_2015.sflb.ashx . 15 July 2015 . dead .
4. Web site: Stretch E . 1 September 2013 . Festivalgoer's death prompts drug warning. . The Guardian .