5-Androstenedione Explained

5-Androstenedione, also known as androst-5-ene-3,17-dione, is a prohormone of testosterone. The World Anti-Doping Agency prohibits its use in athletes. In the United States, it is a controlled substance. 5-Androstenedione is structurally similar to 4-androstenedione, with the exception of the position of a carbon-carbon double bond.

4-Androstenedione is naturally produced in the body by the adrenal glands and gonads. In addition to testosterone, it is also a precursor of estrone and estradiol.[1] [2]

5-Androstenedione is on the World Anti-Doping Agency's list of prohibited substances,[3] and is therefore banned from use in most major sports.

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Notes and References

  1. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS . 6 . DrugBank 3.0: a comprehensive resource for 'omics' research on drugs . Nucleic Acids Research . 39 . Database issue . D1035–D1041 . January 2011 . 21059682 . 3013709 . 10.1093/nar/gkq1126 .
  2. Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M . 6 . DrugBank: a knowledgebase for drugs, drug actions and drug targets . Nucleic Acids Research . 36 . Database issue . D901–D906 . January 2008 . 18048412 . 2238889 . 10.1093/nar/gkm958 . David S. Wishart .
  3. Web site: The World Anti-Doping Code: The 2020 Prohibited List. World Anti-Doping Agency. 2019-12-28.

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