O-Acetylbufotenine Explained

O-Acetylbufotenine (5-AcO-DMT, bufotenine acetate) is a tryptamine derivative which produces psychedelic-appropriate responding in animal studies. It is an acylated derivative of bufotenine with higher lipophilicity that allows it to cross the blood–brain barrier; once inside the brain, it is metabolised to bufotenine.^{[1] [2] [3]} It also acts directly as an agonist at 5-HT_1A and 5-HT_1D receptors.^[4]

See also

• 4-AcO-DMT
• 5-EtO-DMT
• 5-HO-AMT
• 5-HO-DiPT

Notes and References

1. https://www.erowid.org/library/books_online/tihkal/tihkal19.shtml Shulgin & Shulgin. TiHKAL #19. 5-HO-DMT
2. Gessner PK, Dankova JB . Brain Bufotenine from Administered Acetylbufotenine: Comparison of Its Tremorgenic Activity with That of N,N-Dimethyltryptamine and 5-Methoxy-N,N-Dimethyltryptamine. . Pharmacologist . January 1975 . 17 . 2 . 259 .
3. Winter JC, Amorosi DJ, Rice KC, Cheng K, Yu AM . Stimulus control by 5-methoxy-N,N-dimethyltryptamine in wild-type and CYP2D6-humanized mice . Pharmacology, Biochemistry, and Behavior . 99 . 3 . 311–5 . September 2011 . 21624387 . 3129464 . 10.1016/j.pbb.2011.05.015 .
4. Glennon RA, Hong SS, Bondarev M, Law H, Dukat M, Rakhi S, Power P, Fan E, Kinneau D, Kamboj R, Teitler M, Herrick-Davis K, Smith C . Binding of O-alkyl derivatives of serotonin at human 5-HT1D beta receptors . Journal of Medicinal Chemistry . 39 . 1 . 314–22 . January 1996 . 8568822 . 10.1021/jm950498t .