5-APDI explained

5-(2-Aminopropyl)-2,3-dihydro-1H-indene (5-APDI), also known as indanylaminopropane (IAP), IAP (psychedelic), 2-API(2-aminopropylindane), indanametamine, and, incorrectly, as indanylamphetamine,^[1] is an entactogen and psychedelic drug of the amphetamine family.^{[2] [3]} It has been sold by online vendors through the Internet and has been encountered as a designer drug since 2003,^[1] but its popularity and availability has diminished in recent years.

5-APDI acts as a potent and weakly selective serotonin releasing agent (SSRA) with IC₅₀ values of 82 nM, 1,848 nM, and 849 nM for inhibiting the reuptake of serotonin, dopamine, and norepinephrine, respectively.^{[2] [3]} It fully substitutes for MBDB but not amphetamine in trained animals, though it does produce disruption for the latter at high doses.^[2]

5-APDI has been classified as a class B drug under the Misuse of Drugs Act 1971 since 10 June 2014.

See also

• DiFMDA
• 5-MAPDI
• 6-APT

External links

• The Vaults of Erowid - Indanylaminopropane
• MadMax - Illustrated Synthesis of Indanylaminopropane

Notes and References

1. Casale JF, McKibben TD, Bozenko JS, Hays PA . Characterization of the "Indanylamphetamines" . Microgram Journal . 3 . 1–2 . 3–10 . 2005 . 2009-08-06 . https://web.archive.org/web/20090317054109/http://www.usdoj.gov/dea/programs/forensicsci/microgram/journal_v3/mj05_v3_pg1.html . 2009-03-17 . dead .
2. Monte AP, Marona-Lewicka D, Cozzi NV, Nichols DE . Synthesis and pharmacological examination of benzofuran, indan, and tetralin analogues of 3,4-(methylenedioxy)amphetamine . Journal of Medicinal Chemistry . 36 . 23 . 3700–6 . November 1993 . 8246240 . 10.1021/jm00075a027.
3. Parker MA, Marona-Lewicka D, Kurrasch D, Shulgin AT, Nichols DE . Synthesis and pharmacological evaluation of ring-methylated derivatives of 3,4-(methylenedioxy)amphetamine (MDA) . Journal of Medicinal Chemistry . 41 . 6 . 1001–5 . March 1998 . 9526575 . 10.1021/jm9705925. 10.1.1.688.9559 .