Dihydrodeoxycorticosterone Explained

5α-Dihydrodeoxycorticosterone (abbreviated as DHDOC), also known as 21-hydroxy-5α-pregnan-20-one, is an endogenous progestogen and neurosteroid.[1] It is synthesized from the adrenal hormone deoxycorticosterone (DOC) by the enzyme 5α-reductase type I. DHDOC is an agonist of the progesterone receptor, as well as a positive allosteric modulator of the GABAA receptor, and is known to have anticonvulsant effects.[2]

Chemistry

See also: List of neurosteroids.

See also

Notes and References

  1. Reddy DS, Rogawski MA . Stress-induced deoxycorticosterone-derived neurosteroids modulate GABA(A) receptor function and seizure susceptibility . J. Neurosci. . 22 . 9 . 3795–805 . May 2002 . 11978855 . 10.1523/JNEUROSCI.22-09-03795.2002 . 6758375 . free.
  2. Edwards HE, Vimal S, Burnham WM . The acute anticonvulsant effects of deoxycorticosterone in developing rats: role of metabolites and mineralocorticoid-receptor responses . Epilepsia . 46 . 12 . 1888–97 . December 2005 . 16393154 . 10.1111/j.1528-1167.2005.00295.x . 26030656 . free.

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