5α-Dihydrocorticosterone explained

5α-Dihydrocorticosterone (5α-DHC, 5α-DHB), also known as 11β,21-dihydroxy-5α-pregnane-3,20-dione, is a naturally occurring, endogenous glucocorticoid steroid hormone and neurosteroid.^{[1] [2] [3]} It is biosynthesized from corticosterone by the enzyme 5α-reductase.^{[4] [5] [6]} DHC has central depressant effects and impairs long-term potentiation in animals.^{[7] [8]}

See also

• Tetrahydrocorticosterone
• 5α-Dihydroprogesterone
• Dihydrodeoxycorticosterone
• Tetrahydrodeoxycorticosterone
• Allopregnanolone

Notes and References

1. Book: R.A. Hill. H.L.J. Makin. D.N. Kirk. G.M. Murphy. Dictionary of Steroids. 23 May 1991. CRC Press. 978-0-412-27060-4. 218–.
2. McInnes. K. J.. Kenyon. C. J.. Chapman. K. E.. Livingstone. D. E. W.. Macdonald. L. J.. Walker. B. R.. Andrew. R.. 5 -Reduced Glucocorticoids, Novel Endogenous Activators of the Glucocorticoid Receptor. Journal of Biological Chemistry. 279. 22. 2004. 22908–22912. 0021-9258. 10.1074/jbc.M402822200. 15044432. free.
3. Magnaghi V . GABA and neuroactive steroid interactions in glia: new roles for old players? . Curr Neuropharmacol . 5 . 1 . 47–64 . 2007 . 18615153 . 2435342 . 10.2174/157015907780077132.
4. Book: Abraham Weizman. Neuroactive Steroids in Brain Function, Behavior and Neuropsychiatric Disorders: Novel Strategies for Research and Treatment. 1 February 2008. Springer Science & Business Media. 978-1-4020-6854-6. 48–.
5. Book: Neurosteroids and Brain Function. 12 December 2001. Academic Press. 978-0-08-054423-6. 147–.
6. Book: N. Kato. M. Kawata. R.K. Pitman. PTSD: Brain Mechanisms and Clinical Implications. 3 July 2007. Springer Science & Business Media. 978-4-431-29567-9. 125–.
7. Dubrovsky. B.. Williams. D.. Kraulis. I.. Effects of corticosterone and 5?-dihydrocorticosterone on brain excitability in the rat. Journal of Neuroscience Research. 14. 1. 1985. 117–128. 0360-4012. 10.1002/jnr.490140111. 4020896 . 84291184 .
8. Dubrovsky. B.O.. Liquornik. M.S.. Noble. P.. Gijsbers. K.. Effects of 5α-dihydrocorticosterone on evoked responses and long-term potentiation. Brain Research Bulletin. 19. 6. 1987. 635–638. 0361-9230. 10.1016/0361-9230(87)90049-9. 3440216 . 54274436 .