Androstanedione Explained

Androstanedione, also known as 5α-androstanedione or as 5α-androstane-3,17-dione, is a naturally occurring androstane (5α-androstane) steroid and an endogenous metabolite of androgens like testosterone, dihydrotestosterone (DHT), dehydroepiandrosterone (DHEA), and androstenedione.[1] It is the C5 epimer of etiocholanedione (5β-androstanedione). Androstanedione is formed from androstenedione by 5α-reductase and from DHT by 17β-hydroxysteroid dehydrogenase.[2] [3] It has some androgenic activity.[4]

In female genital skin, the conversion of androstenedione into DHT through 5α-androstanedione appears to be more important than the direct conversion of testosterone into DHT.[5]

External links

Notes and References

  1. Web site: Human Metabolome Database: Showing metabocard for Androstanedione (HMDB0000899).
  2. Book: Kenneth L. Becker. Principles and Practice of Endocrinology and Metabolism. 2001. Lippincott Williams & Wilkins. 978-0-7817-1750-2. 994–.
  3. Book: Eric S. Orwoll. John P. Bilezikian. Dirk Vanderschueren. Osteoporosis in Men: The Effects of Gender on Skeletal Health. 30 November 2009. Academic Press. 978-0-08-092346-8. 296–.
  4. Book: Charles D. Kochakian. Anabolic-Androgenic Steroids. 6 December 2012. Springer Science & Business Media. 978-3-642-66353-6. 171–.
  5. Stanczyk FZ . Diagnosis of hyperandrogenism: biochemical criteria . Best Pract Res Clin Endocrinol Metab . 20 . 2 . 177–91 . June 2006 . 16772150 . 10.1016/j.beem.2006.03.007 .

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