40S ribosomal protein S26 explained

40S ribosomal protein S26 is a protein that in humans is encoded by the RPS26 gene.^{[1] [2] [3]}

Function

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S26E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[3]

Further reading

• Wool IG, Chan YL, Glück A . Structure and evolution of mammalian ribosomal proteins. . Biochem. Cell Biol. . 73 . 11–12 . 933–47 . 1996 . 8722009 . 10.1139/o95-101 .
• Filipenko ML, Vladimirov SN, Muravlev AI, etal . [Cloning cDNA of human S26 ribosomal protein and determination of its primary structure] . Bioorg. Khim. . 20 . 6 . 644–9 . 1994 . 7945460 .
• Vincent S, Marty L, Fort P . S26 ribosomal protein RNA: an invariant control for gene regulation experiments in eucaryotic cells and tissues. . Nucleic Acids Res. . 21 . 6 . 1498 . 1993 . 8464749 . 10.1093/nar/21.6.1498 . 309346 .
• Vladimirov SN, Ivanov AV, Karpova GG, etal . Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry. . Eur. J. Biochem. . 239 . 1 . 144–9 . 1996 . 8706699 . 10.1111/j.1432-1033.1996.0144u.x . free .
• Filipenko ML, Vinichenko NA, Karpova GG, etal . Isolation, structural analysis and mapping of the functional gene of human ribosomal protein S26. . Gene . 211 . 2 . 287–92 . 1998 . 9602156 . 10.1016/S0378-1119(98)00108-5 .
• Xu XR, Huang J, Xu ZG, etal . Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver. . Proc. Natl. Acad. Sci. U.S.A. . 98 . 26 . 15089–94 . 2002 . 11752456 . 10.1073/pnas.241522398 . 64988 . free .
• Ivanov AV, Malygin AA, Karpova GG . [Ribosomal protein binding with the first intron of the human ribosomal protein S26 pre-mRNA stimulates its interaction with proteins extracted from Hela cells] . Mol. Biol. (Mosk.) . 36 . 3 . 503–10 . 2002 . 12068637 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . free . 2002PNAS...9916899M .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Ivanov AV, Malygin AA, Karpova GG . Human ribosomal protein S26 suppresses the splicing of its pre-mRNA. . Biochim. Biophys. Acta . 1727 . 2 . 134–40 . 2005 . 15716004 . 10.1016/j.bbaexp.2004.12.011 .
• Yu Y, Ji H, Doudna JA, Leary JA . Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes. . Protein Sci. . 14 . 6 . 1438–46 . 2005 . 15883184 . 10.1110/ps.041293005 . 2253395 .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Olsen JV, Blagoev B, Gnad F, etal . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
• Tu LC, Yan X, Hood L, Lin B . Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells. . Mol. Cell. Proteomics . 6 . 4 . 575–88 . 2007 . 17220478 . 10.1074/mcp.M600249-MCP200 . 7203032 . free .
• Ewing RM, Chu P, Elisma F, etal . Large-scale mapping of human protein-protein interactions by mass spectrometry. . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 .

External links

• GeneReviews/NCBI/NIH/UW entry on Diamond-Blackfan Anemia

Notes and References

1. Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC . A map of 75 human ribosomal protein genes . Genome Res . 8 . 5 . 509–23 . Aug 1998 . 9582194 . 10.1101/gr.8.5.509. free .
2. Filipenko ML, Mishin VP, ((Suturina IuA)), Muravlev AI, Kopantsev EA, Karpova GG, Mertvetsov NP . [Mapping of the genes for ribosomal proteins S26, L19, and L32 on human chromosomes] . Bioorg Khim . 21 . 11 . 838–44 . Aug 1996 . 8670309 .
3. Web site: Entrez Gene: RPS26 ribosomal protein S26.