40S ribosomal protein S18 explained

40S ribosomal protein S18 is a protein that in humans is encoded by the RPS18 gene.^{[1] [2] [3]}

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S13P family of ribosomal proteins. It is located in the cytoplasm. The gene product of the E. coli ortholog (ribosomal protein S13) is involved in the binding of fMet-tRNA, and thus, in the initiation of translation. This gene is an ortholog of mouse Ke3. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[3]

Further reading

• Wool IG, Chan YL, Glück A . Structure and evolution of mammalian ribosomal proteins. . Biochem. Cell Biol. . 73 . 11–12 . 933–47 . 1996 . 8722009 . 10.1139/o95-101 .
• Chan YL, Paz V, Wool IG . The primary structure of rat ribosomal protein S18. . Biochem. Biophys. Res. Commun. . 178 . 3 . 1212–8 . 1991 . 1872840 . 10.1016/0006-291X(91)91022-5 . 335161 .
• Chassin D, Bénifla JL, Delattre C, etal . Identification of genes overexpressed in tumors through preferential expression screening in trophoblasts. . Cancer Res. . 54 . 19 . 5217–23 . 1994 . 7923143 .
• Vladimirov SN, Ivanov AV, Karpova GG, etal . Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry. . Eur. J. Biochem. . 239 . 1 . 144–9 . 1996 . 8706699 . 10.1111/j.1432-1033.1996.0144u.x . free .
• Andersen JS, Lyon CE, Fox AH, etal . Directed proteomic analysis of the human nucleolus. . Curr. Biol. . 12 . 1 . 1–11 . 2002 . 11790298 . 10.1016/S0960-9822(01)00650-9 . 14132033 . free . 2002CBio...12....1A .
• Mishra-Gorur K, Singer HA, Castellot JJ . The S18 ribosomal protein is a putative substrate for Ca2+/calmodulin-activated protein kinase II. . J. Biol. Chem. . 277 . 37 . 33537–40 . 2002 . 12145273 . 10.1074/jbc.C200342200 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Mungall AJ, Palmer SA, Sims SK, etal . The DNA sequence and analysis of human chromosome 6. . Nature . 425 . 6960 . 805–11 . 2003 . 14574404 . 10.1038/nature02055 . 2003Natur.425..805M . free .
• Kusui K, Sasaki H, Adachi R, etal . Ribosomal protein S18 identified as a cofilin-binding protein by using phage display library. . Mol. Cell. Biochem. . 262 . 1–2 . 187–93 . 2005 . 15532723 . 10.1023/B:MCBI.0000038234.35936.1c . 30534195 .
• Andersen JS, Lam YW, Leung AK, etal . Nucleolar proteome dynamics. . Nature . 433 . 7021 . 77–83 . 2005 . 15635413 . 10.1038/nature03207 . 2005Natur.433...77A . 4344740 .
• Yu Y, Ji H, Doudna JA, Leary JA . Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes. . Protein Sci. . 14 . 6 . 1438–46 . 2005 . 15883184 . 10.1110/ps.041293005 . 2253395 .

Notes and References

1. Chassin D, Bellet D, Koman A . The human homolog of ribosomal protein S18 . Nucleic Acids Res . 21 . 3 . 745 . Mar 1993 . 8441687 . 309181 . 10.1093/nar/21.3.745 .
2. Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC . A map of 75 human ribosomal protein genes . Genome Res . 8 . 5 . 509–23 . Aug 1998 . 9582194 . 10.1101/gr.8.5.509. free .
3. Web site: Entrez Gene: RPS18 ribosomal protein S18.