40S ribosomal protein S17 explained

40S ribosomal protein S17 is a protein that in humans is encoded by the RPS17 gene.^{[1] [2] [3]}

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S17E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[3]

Further reading

• Wool IG, Chan YL, Glück A . Structure and evolution of mammalian ribosomal proteins. . Biochem. Cell Biol. . 73 . 11–12 . 933–47 . 1996 . 8722009 . 10.1139/o95-101 .
• Chen IT, Roufa DJ . The transcriptionally active human ribosomal protein S17 gene . Gene . 70 . 1 . 107–16 . 1989 . 3240863 . 10.1016/0378-1119(88)90109-6 .
• Chen IT, Dixit A, Rhoads DD, Roufa DJ . Homologous ribosomal proteins in bacteria, yeast, and humans . Proc. Natl. Acad. Sci. U.S.A. . 83 . 18 . 6907–11 . 1986 . 3529092 . 10.1073/pnas.83.18.6907 . 386619 . 1986PNAS...83.6907C . free .
• Mundus DA . Structural arrangement of the codon-anticodon interaction area in human placenta ribosomes. Affinity labelling of the 40S subunits by derivatives of oligoribonucleotides containing the AUG codon . Biochim. Biophys. Acta . 1173 . 3 . 273–82 . 1993 . 8318536 . 10.1016/0167-4781(93)90124-v. vanc. Bulygin KN . Yamkovoy VI . 3 . Malygin . AA . Repkova . MN . Vratskikh . LV . Venijaminova . AG . Vladimirov . SN . Karpova . GG .
• Vladimirov SN . Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry . Eur. J. Biochem. . 239 . 1 . 144–9 . 1996 . 8706699 . 10.1111/j.1432-1033.1996.0144u.x . vanc. Ivanov AV . Karpova GG . 3 . Musolyamov . Alekxander K. . Egorov . Tsezi A. . Thiede . Bernd . Wittmann-Liebold . Brigitte . Otto . Albrecht . free .
• Patel HR, Terada N, Gelfand EW . Rapamycin-sensitive phosphorylation of ribosomal protein S17 by p70 S6 kinase . Biochem. Biophys. Res. Commun. . 227 . 2 . 507–12 . 1996 . 8878544 . 10.1006/bbrc.1996.1537 .
• Kenmochi N . A map of 75 human ribosomal protein genes . Genome Res. . 8 . 5 . 509–23 . 1998 . 9582194 . 10.1101/gr.8.5.509 . vanc. Kawaguchi T . Rozen S . 3 . Davis . E . Goodman . N . Hudson . TJ . Tanaka . T . Page . DC. free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Ballif BA . Phosphoproteomic analysis of the developing mouse brain . Mol. Cell. Proteomics . 3 . 11 . 1093–101 . 2005 . 15345747 . 10.1074/mcp.M400085-MCP200 . vanc. Villén J . Beausoleil SA . 3 . Schwartz . D . Gygi . SP . free .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Andersen JS . Nucleolar proteome dynamics . Nature . 433 . 7021 . 77–83 . 2005 . 15635413 . 10.1038/nature03207 . vanc. Lam YW . Leung AK . 3 . Ong . Shao-En . Lyon . Carol E. . Lamond . Angus I. . Mann . Matthias . 2005Natur.433...77A . 4344740 .
• Yu Y, Ji H, Doudna JA, Leary JA . Mass spectrometric analysis of the human 40S ribosomal subunit: Native and HCV IRES-bound complexes . Protein Sci. . 14 . 6 . 1438–46 . 2005 . 15883184 . 10.1110/ps.041293005 . 2253395 .

External links

• GeneReviews/NCBI/NIH/UW entry on Diamond-Blackfan Anemia

Notes and References

1. Feo S, Davies B, Fried M . The mapping of seven intron-containing ribosomal protein genes shows they are unlinked in the human genome . Genomics . 13 . 1 . 201–7 . Jun 1992 . 1577483 . 10.1016/0888-7543(92)90221-D .
2. Filipenko ML, Iantsen EI, Muravlev AI, Kopantsev EP, Karpova GG, Mertvetsov NP . [Mapping the genes for ribosomal proteins S14 and S17 on human chromosomes using cDNA from a panel of hybrid cells] . Bioorg Khim . 21 . 5 . 349–53 . Oct 1995 . 7661859 .
3. Web site: Entrez Gene: RPS17 ribosomal protein S17.