4-Piperidone Explained

4-Piperidone is an organic compound with the molecular formula . It can be viewed as a derivative of piperidine. 4-Piperidone is used as an intermediate in the manufacture of chemicals and pharmaceutical drugs. Substituted and dehydro derivatives of 4-piperidinone are intermediates in alkaloid syntheses.^[1]

It is a List I chemical in the United States. It is a precursor to fentanyl.

The N-protonated derivative is typically isolated as the hydrate .^[2]

See also

• 4-Pyridone

Notes and References

1. 10.1016/s0040-4020(03)00295-3 . Recent advances in the synthesis of piperidones and piperidines . 2003 . Weintraub . Philip M. . Sabol . Jeffrey S. . Kane . John M. . Borcherding . David R. . Tetrahedron . 59 . 17 . 2953–2989 .
2. 10.1002/anie.201408278 . Cation-Cation Pairing by N-C-H⋅⋅⋅O Hydrogen Bonds . 2015 . Gamrad . Waltraud . Dreier . Angelika . Goddard . Richard . Pörschke . Klaus-Richard . Angewandte Chemie International Edition . 54 . 15 . 4482–4487 . 25712229 .