4-phosphoerythronate dehydrogenase explained

4-phosphoerythronate dehydrogenase
Ec Number:	1.1.1.290

In enzymology, a 4-phosphoerythronate dehydogenase is an enzyme that catalyzes the chemical reaction

4-phospho-D-erythronate + NAD⁺

\rightleftharpoons (3R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + NADH + H⁺

Thus, the two substrates of this enzyme are 4-phospho-D-erythronate and NAD⁺, whereas its 3 products are (3R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is 4-phospho-D-erythronate:NAD⁺ 2-oxidoreductase. Other names in common use include PdxB, PdxB 4PE dehydrogenase, and 4-O-phosphoerythronate dehydrogenase. This enzyme participates in vitamin B₆ metabolism.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code .

References

• Lam HM, Winkler ME . 1990 . Metabolic relationships between pyridoxine (vitamin B6) and serine biosynthesis in Escherichia coli K-12 . J. Bacteriol. . 172 . 6518–28 . 2121717 . 11 . 10.1128/jb.172.11.6518-6528.1990 . 526841 .
• Pease AJ, Roa BR, Luo W, Winkler ME . 2002 . Positive growth rate-dependent regulation of the pdxA, ksgA, and pdxB genes of Escherichia coli K-12 . J. Bacteriol. . 184 . 1359–69 . 11844765 . 10.1128/JB.184.5.1359-1369.2002 . 5 . 134838 .
• Zhao G, Winkler ME . 1996 . A novel alpha-ketoglutarate reductase activity of the serA-encoded 3-phosphoglycerate dehydrogenase of Escherichia coli K-12 and its possible implications for human 2-hydroxyglutaric aciduria . J. Bacteriol. . 178 . 232–9 . 8550422 . 1 . 10.1128/jb.178.1.232-239.1996 . 177644 .
• Grant GA . 1989 . A new family of 2-hydroxyacid dehydrogenases . Biochem. Biophys. Res. Commun. . 165 . 1371–4 . 2692566 . 10.1016/0006-291X(89)92755-1 . 3 .
• Schoenlein PV, Roa BB, Winkler ME . 1989 . Divergent transcription of pdxB and homology between the pdxB and serA gene products in Escherichia coli K-12 . J. Bacteriol. . 171 . 6084–92 . 2681152 . 11 . 10.1128/jb.171.11.6084-6092.1989 . 210475 .