4-methyleneglutamate—ammonia ligase explained

4-Methyleneglutamate—ammonia ligase
Ec Number:	6.3.1.7
Cas Number:	85537-85-5
Go Code:	0047581

In enzymology, a 4-methyleneglutamate—ammonia ligase is an enzyme that catalyzes the chemical reaction

ATP + 4-methylene-L-glutamate + NH₃

\rightleftharpoons AMP + diphosphate + 4-methylene-L-glutamine

The 3 substrates of this enzyme are ATP, 4-methylene-L-glutamate, and NH₃, whereas its 3 products are AMP, diphosphate, and 4-methylene-L-glutamine.

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-ammonia (or amine) ligases (amide synthases). The systematic name of this enzyme class is 4-methylene-L-glutamate:ammonia ligase (AMP-forming). This enzyme is also called 4-methyleneglutamine synthetase. This enzyme participates in c5-branched dibasic acid metabolism.

References

• Winter HC, Su TZ, Dekker EE . 1983 . 4-methyleneglutamine synthetase: a new amide synthetase present in germinating peanuts . Biochem. Biophys. Res. Commun. . 111 . 484–9 . 6838571 . 10.1016/0006-291X(83)90332-7 . 2 . 2027.42/25265 . free .