4-Methylaminobutanoate oxidase (methylamine-forming) explained

4-methylaminobutanoate oxidase (methylamine-forming)
Ec Number:	1.5.3.21

4-methylaminobutanoate oxidase (methylamine-forming) (mao (gene)) is an enzyme with systematic name 4-methylaminobutanoate methylamidohydrolase.^{[1] [2]} This enzyme catalyses the following chemical reaction

4-methylaminobutanoate + O₂ + H₂O

\rightleftharpoons succinate semialdehyde + methylamine + H₂O₂

The enzyme participates in the nicotine degradation in soil bacterium Arthrobacter nicotinovorans.

Notes and References

1. Chiribau CB, Sandu C, Fraaije M, Schiltz E, Brandsch R . A novel gamma-N-methylaminobutyrate demethylating oxidase involved in catabolism of the tobacco alkaloid nicotine by Arthrobacter nicotinovorans pAO1 . European Journal of Biochemistry . 271 . 23–24 . 4677–84 . December 2004 . 15606755 . 10.1111/j.1432-1033.2004.04432.x . free .
2. Chiribau CB, Mihasan M, Ganas P, Igloi GL, Artenie V, Brandsch R . Final steps in the catabolism of nicotine . The FEBS Journal . 273 . 7 . 1528–36 . April 2006 . 16689938 . 10.1111/j.1742-4658.2006.05173.x . free .